Natural ‘breakdown’ of chemicals to guard against lung damage

According to a new study, when fats, carbohydrates and proteins are broken down inside the body, there are certain chemicals present there which can predict Whether first responders from 11th September, 2001 who, at the world trade center, were exposed to toxic dust would as a result develop lung disease

NYU School of Medicine researchers say that they have, for the first time, successfully experimented the suggestion of compounds that may have played a part in the prevention of disease in the firefighters and emergency workers. Specifically, 30 such chemicals were linked in their study —also known as metabolites—to increase protection in opposition to OAD, obstructive airway disease, which blocks the flow of air from the lungs. While protected ones had low levels of metabolites, they had larger amounts in comparison with first responders who developed the disease since 9/11.

On the basis of these metabolic predictors, researchers are hoping that dietary changes, drugs, and regular exercise have the ability to protect people exposed to toxicity of fire and smoke. The current study includes protective chemicals such as omega-3 fatty acids and protein-building amino acids, which can readily be obtained, from diets which are rich in olive oil and fish (e.g., Mediterranean diet).

The previous work is followed by the latest results, published by the same team last year, which made identification of more than 2 dozen other metabolites, whose occurrence was at lower levels in those firefighters who did not end up developing lung disease.

Anna Nolan, a study senior investigator and an associate professor in the Department of Medicine at NYU Langone Health said that their new work showed that some metabolites might actually safeguard 1st responders from the loss of their lung function. By forming the combination of results of their studies to date, they were closer to predicting who got lung damage. This, in turn, offered unique opportunities regarding improved diagnosis and stopping of obstructive airway disease taking the next step.

For the new study, that is to be published online on 3rd September in the journal Scientific Reports, blood samples were analyzed, by researchers, from 14,000 9/11 1st responders (EMS workers and firefighters) whose lung function was tested before the disaster, after it happened, and each year since then. From the 594 common metabolites that are in human body, researchers then made identification of most closely tied metabolites to the 1st responders showing no signs of OAD.